Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-term Effectiveness (ADAPTABLE)
PI(s): Matthew Roe, MD, Duke University
PaTH Protocol PI(s):
Purpose: Clinicians often prescribe aspirin to prevent strokes and heart attacks in people living with heart disease. Research has yet to determine the best dose to use to get maximum benefit while minimizing risks, like increased bleeding.
Goal(s): To understand the dose of aspirin that prevents strokes and heart attacks, while minimizing the risk of bleeding.
Study Design: Pragmatic Randomized Clinical Trial
Patients who have heart disease and are at high risk of having a heart attack or stroke will be randomly assigned to use low or regular strength aspirin and followed up to 30 months.
Researchers will look at benefits and side effects not just overall, but also by gender, age, ethnicity, and race, as well as in patients with medical conditions in addition to heart disease, such as diabetes. It’s a far cry from traditional studies that assess what works for the “average” patient.
Coordinating Center: Duke University Clinical Research Institute
How to Participate: If you are eligible, you may be contacted by PaTH research staff.