PREVENTABLE Study Spotlight

The PaTH Network is currently recruiting participants for the PREVENTABLE Study: PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldER adults. The goal of this project is to learn whether a statin medication (commonly used for lowering cholesterol) is also able to prevent dementia and other cognitive disabilities in older adults without cardiovascular disease.

The PREVENTABLE trial involves researchers, clinicians, community partners, advisors, and over 20,000 older adults, as well as a group of Veterans Administration (VA) medical centers. It is funded by the National Institutes of Health (NIH). Across the country, there are one hundred health systems and over fifty VA medical centers participating in the study, including institutions that are part of PCORnet, the National Patient-Centered Clinical Research Network.

PREVENTABLE is a pragmatic study, meaning that part of the study model is reaching out to participants on their own schedules, often through video chat, phone calls, or home visits. This makes PREVENTABLE extremely patient-centered; patient partners do not have to arrange their lives around this study, and that is by design. Study participants can enroll over the phone or by Zoom and receive the study drug by mail. Half of them will receive the statin medication and the other half, a placebo (inactive) pill that looks just like the statin medication. Three of the PaTH sites are participating: Johns Hopkins University, the Ohio State University, and the University of Pittsburgh. Fifty-one adults have been enrolled in this study at JHU, 22 at OSU, and 109 at Pitt.

Dr. Daniel Forman represents PaTH on the PREVENTABLE Study’s core leadership team and serves as the Site Principal Investigator at the University of Pittsburgh. At the University of Pittsburgh, he is a geriatric cardiologist and the Chair of the Section of Geriatric Cardiology in the School of Medicine. When asked why this study is so important, Dr. Forman noted, "A driving principle for this trial is that optimal care for older adults is not necessarily fewer medications, but rather, the right medications; PREVENTABLE will help clarify if statins are beneficial."

If this study is of interest to you, click here to see local study locations, and talk to your healthcare providers about PREVENTABLE.

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