Cognitive Behavioral Therapy and Real-Time Pain Management Intervention for Sickle Cell via Mobile Applications (CaRISMA)

Project Summary: We are conducting a comparative effectiveness trial among adult patients with sickle cell disease (SCD) who report chronic pain (N = 350), randomized to receive either mobile phone-delivered computerized cognitive behavioral therapy (cCBT; n = 175) or digital education (m-Education; n = 175). Both intervention groups will receive weekly (more frequent if requested or needed) follow-up with a health coach for at least 3 months to reinforce learned materials. Both groups will also use their mobile device to track daily pain, mood, and medication used for two-week periods at baseline and each of the follow-up points (3, 6 and 12 months). They will also be given access to a study-associated online support group page where they can discuss with other patients, issues they faced and what skills were or could be used to address them. Participants will continue all routine care including opioid pain management and novel therapies.

PI(s): Charles Jonassaint, PhD MHS, Kaleab Z. Abebe, PhD, Laura De Castro, Nirmish Shah, Victor Gordeuk, Sophie Lanzkron, Payal Desi

Purpose: To compare cCBT therapy against m-Education to see which provides a greater benefit for daily pain. We also seek to understand if cCBT will provide a greater benefit to depressive symptoms, health care utilization, and opioid misuse behaviors compared to m-Education as well as measure the feasibility of these measures.

Goal(s): To provide better coping tools for patients with daily pain and depression

Study Design: Clinical Trial

PCORnet Partners: University of Pittsburgh, Ohio State University, Duke University, University of Chicago at Illinois, Johns Hopkins University

PaTH Partners: University of Pittsburgh, Ohio State University, Duke University, University of Chicago at Illinois, Johns Hopkins University

Sponsor: PCORI

Coordinating Center: University of Pittsburgh

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