PCORnet Bariatric Study

Project Summary

PI(s):

• David Arterburn, MD, MPH, Group Health Research Institute
• Kathleen McTigue, MD, University of Pittsburgh, UPMC, PaTH CDRN
• Neely Williams, M.Div, Patient Partner, Mid-South CDRN

PaTH Protocol PI(s):

• Jeanne Clark, MD, MPH, Johns Hopkins University and Johns Hopkins Medicine (JHM) (Lead)
• Anita Courcoulas, MD, MPH, University of Pittsburgh, UPMC (Core Scientific Team)
• Julie Tice, Patient Partner, PaTH CDRN
• Jennifer Kraschnewski, MD, MPH, Penn State Milton S. Hershey Medical Center, Penn State College of Medicine
• Anuradha Paranjape, MD, MPH, FACP, Lewis Katz School of Medicine at Temple University, Temple Health
• Michelle Lent, PhD, Geisinger Obesity Institute, Geisinger Health System

Purpose: The use of bariatric surgery as a treatment for severe obesity has increased dramatically over the past two decades, but there have been few high-quality, long-term studies comparing the outcomes of different procedures.

Goal(s): The main goal of the proposed study is to provide accurate estimates of the one-, three-, and five-year benefits and risks of the three most common bariatric procedures—Roux-en-y gastric bypass, adjustable gastric banding, and sleeve gastrectomy—with a focus on outcomes that are important to adults and adolescents with severe obesity. These include, (a) changes in weight; (b) remission and relapse of diabetes; and (c) risk of major adverse events.

Study Design: Obesity Observational Research Initiative

The study will involve 10 of PCORnet’s Clinical Research Networks (CDRNs) including 53 healthcare organizations and more than 60,000 bariatric patients, with 50 percent gastric bypass, 10 percent gastric banding, and 40 percent sleeve gastrectomy procedures. This study will also include more than 900 adolescent bariatric patients (the largest adolescent cohort ever) and more than 17,000 patients with diabetes.

PaTH Partners:

• Johns Hopkins University and Johns Hopkins Medicine
• Lewis Katz School of Medicine at Temple University, Temple Health
• Penn State Milton S. Hershey Medical Center, Penn State College of Medicine
• University of Pittsburgh, UPMC
• Geisinger Health System

PCORnet Partners /CDRN Participating Sites:

• CAPriCORN – The Alliance of Chicago Community Health Services, Loyola University Health System, NorthShore University Health System, Northwestern Medicine, Rush University Medical Center, The University of Chicago Medicine, University of Illinois Hospital & Health Sciences System, Hines VA Medical Center
• GPC – Marshfield Clinic, Kansas University Medical Center, University of Iowa, Medical College of Wisconsin, University of Nebraska Medical Center, UT Southwestern Medical Center, UT San Antonio, University of Wisconsin – Madison, University of Utah, University of Utah Health
• LACDRN – Ochsner Health System, Pennington Biomedical Research Center, Tulane University, Partnership for Achieving Total Health (PATH)
• Mid-South – Vanderbilt, Vanderbilt Health Network, Greenway
• NYC-CDRN – New York University, Mount Sinai, Montefiore/Einstein, Columbia, Weill Cornell Medical Center, Rockefeller
• PaTH – University of Pittsburgh and UPMC, Penn State College of Medicine and Hershey Medical Center, Temple University Health System, Johns Hopkins University Health System, University of Utah and University of Utah Health, Geisinger Health System
• PEDSnet – Cincinnati Children’s Hospital Medical Center, Boston Children’s Hospital, Nemours, Nationwide
• PORTAL – Kaiser Permanente (KP) Colorado , KP Southern California, KP Northwest, KP Mid-Atlantic States, Group Health Research Institute, HealthPartners Institute for Education and Research
• pSCANNER – University of California at San Diego, University of California at Irvine, University of California at Los Angeles, Tennessee Valley Veterans Affairs
• SCILHS – Partners HealthCare, Wake Forrest Baptist Hospital, Beth Israel Deaconess Medical Center, Boston Medical Center

Sponsor: PCORI

Coordinating Center: Group Health Cooperative

Fact Sheet