Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-term Effectiveness (ADAPTABLE)

Project Summary
Study Website

PI(s): Matthew Roe, MD, Duke University

PaTH Protocol PI(s):

  • Sandeep K. Jain, MD, University of Pittsburgh, UPMC (Lead)
  • Jennifer L. Kraschnewski, MD, MPH, Penn State Milton S. Hershey Medical Center, Penn State College of Medicine (Lead)

Purpose: Clinicians often prescribe aspirin to prevent strokes and heart attacks in people living with heart disease. Research has yet to determine the best dose to use to get maximum benefit while minimizing risks, like increased bleeding.

Goal(s): To understand the dose of aspirin that prevents strokes and heart attacks, while minimizing the risk of bleeding.

Study Design: Pragmatic Randomized Clinical Trial

Patients who have heart disease and are at high risk of having a heart attack or stroke will be randomly assigned to use low or regular strength aspirin and followed up to 30 months.

Researchers will look at benefits and side effects not just overall, but also by gender, age, ethnicity, and race, as well as in patients with medical conditions in addition to heart disease, such as diabetes. It’s a far cry from traditional studies that assess what works for the “average” patient.

PCORnet Partners:

  • Chicago Area Patient-Centered Outcomes Research Network (CAPriCORN)
  • Greater Plains Collaborative CDRN, based at the University of Kansas Medical Center, Kansas City
  • REACHnet Research Action for Health Network, Louisiana Public Health Institute
  • Mid-South CDRN, based at Vanderbilt University, Nashville, Tennessee
  • New York City CDRN, based at Weill Medical College of Cornell University
  • pSCANNER: Patient-centered SCAlable National Network for Effectiveness Research, University of California, San Diego
  • The Health eHeart Alliance PPRN, University of California, San Francisco
  • OneFlorida Clinical Data Research Network, University of Florida

PaTH Partners:

  • Johns Hopkins University and Johns Hopkins Health System
  • Lewis Katz School of Medicine at Temple University, Temple Health
  • Penn State Milton S. Hershey Medical Center, Penn State College of Medicine
  • University of Pittsburgh, UPMC
  • University of Utah, University of Utah Health

Sponsor: PCORI

Coordinating Center: Duke University Clinical Research Institute

Fact Sheet

How to Participate: If you are eligible, you may be contacted by PaTH research staff.

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